Defective Drugs Cases...
DES (Diethylstilbestrol) Related Side Affects....

   Children and grandchildren of women who took DES (Diethylstilbestrol) during pregnancy are at an increased risk of developing significant injuries ranging from rare cancers to genital abnormalities. We represent victims who have suffered from side effects of DES.

   All DES daughters (women whose mothers took DES while pregnant with them) have a risk of about 1 in 1,000 for a rare cancer of the vagina or cervix called clear cell adenocarcinoma. If you or someone you know has been diagnosed with clear cell adenocarcinoma, we urge you to contact the DES Cancer Network. This cancer is practically non-existent in non-exposed women in this age group. Because of this risk DES daughters need a special exam at least once a year. DES Daughters have an increased risk for infertility. Infertility treatments for DES daughters are, in general, not different from those for other women. DES daughters may want to see a doctor experienced in treating DES-exposed women.

   DES Daughters have a higher risk for ectopic pregnancy, miscarriage, and preterm labor and delivery. Most DES daughters can become pregnant and carry their babies to term. However, because of the above risks, all DES daughters (whether they have had previous normal pregnancies or not) require high risk obstetric care and early confirmation of pregnancy. DES daughters should have their pregnancies confirmed by a health care provider as soon as pregnancy is suspected, and should be seen more frequently throughout their pregnancies. DES daughters have an increased incidence of structural changes in their reproductive organs. These may or may not be linked to pregnancy problems, and are not known to be linked to cancer.

   Although less is known about the consequences of DES exposure in men than in women, a number of concerns have been identified. It is important for men who know or suspect they are DES sons to be aware of possible problems and know what to do about them. Most men exposed to DES before birth have no known increased risk of health problems. However, some DES sons do face an increased risk for problems with their genital organs. These range from harmless irregularities to problems which may require medical treatment. Many people, including some doctors, do not know that men can be affected by DES exposure before birth. Epididymal cysts are the most common abnormality in DES sons.

   The epididymis is a structure on the back of each testicle where sperm are stored. Epididymal cysts are non-cancerous growths that feel like small lumps. They may disappear and recur over time. They do not need to be treated unless they are painful. However, report all lumps to your doctor and perform testicular self-exams on a monthly basis. Testicular problems in some men exposed to DES include both small testicles and undescended testicles. Both of these abnormalities are visible at birth. Men with undescended testicles have an increased chance of developing testicular cancer, even if their mothers didn't take DES. An abnormally small penis (microphallus) occurs more often in DES sons than in other men.

   Some studies have indicated that testicular varicoceles occur more often in DES sons than in other men. A varicocele is an irregularly swollen or varicose vein on the testicle. This enlarged vein produces a higher temperature than is normal for testicles, and - over a period of years - can lower the number of normal sperm as a result. Hypospadias is a condition where the opening of the penis is located on the under-surface of the penis rather than at the end.

   A 1995 study comparing a group of men exposed to DES to a group of men not exposed to DES found that DES had no effect on fertility. The men in this study were all born between 1950 and 1953. The study measured the following factors as indicators of fertility: whether the men had ever impregnated a woman, age at the birth of their first child, average number of children, medical diagnosis of a fertility problem, or length of time to conception in the most recent pregnancy of the female partner. There was no semen analysis done in this study, and thus we do not know whether DES sons have, on average, lower sperm counts. This study indicates that DES does not seem to affect fertility in males.

   A new study also finds that grandsons of women who took the drug diethylstilbestrol, or DES, during pregnancy may be more likely to develop an abnormality of the penis.

Other Names:
Misoprostol

Adverse Effects/ Potential Injuries:
Jaundice in Baby
Uterine Hyperstimulation
Blood Loss
Amniotic Fluid Embolism
Uterine Rupture

Related Terms:
Gastric Ulcer

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