Defective Drugs Cases...
Celebrex Related Side Affects....



HOME --- DEFECTIVE DRUGS --- CELEBREX


   Vioxx and Celebrex have been linked by researchers to an increase in the risk of blood clots, heart attacks and strokes. These popular and heavily advertised arthritis drugs, are projected to make somewhere in the neigborhood of $6 billion in 2003.

   In a study of more than 8,000 patients that compared the COX-2 inhibitor rofecoxib (Vioxx) with the traditional NSAID naproxen, the risk of cardiovascular problems, including heart attack, chest pain related to heart disease, stroke, sudden death and blood clots, was more than two times higher in the rofecoxib group than in the naproxen group.

   Vioxx and Celebrex are classified as and known as COX-2 inhibitors, or coxibs. COX-2 inhibitors, like older drugs such as ibuprofen and naproxen, are nonsteroidal anti-inflammatory drugs, or NSAIDs. Older NSAIDs reduce inflammation by blocking an enzyme called COX-2, but they also block another enzyme called COX-1. This enzyme helps protect the lining of the stomach, so blocking COX-2 can cause stomach irritation. COX-2 inhibitors only block COX-2, leaving the stomach-protecting COX-1 alone.

   The annual rates of heart attack in both the Celebrex (celecoxib) and Vioxx (rofecoxib) studies were increased compared to a review of studies containing a total of more than 48,000 patients. In those studies, 0.52% of patients taking an inactive placebo pill had a heart attack each year. The annual rate of heart attack was 0.74% for patients taking rofecoxib and 0.80% for those taking celecoxib.

Other Names:
Celecoxib

Adverse Effects/ Potential Injuries:
Blood Clots
Heart Attack
Stroke

Related Terms:
Vioxx

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